GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THYM | cis | rs2251844 | 1 | rs76542740 | chr15:43891512 | ADAL | chr15:43622872-43646094:+ | -0.49 | -4.35 | 3.37E-5 | Tumor biomarkers |
| THYM | cis | rs73726531 | 1 | rs76574179 | chr6:18152540 | NHLRC1 | chr6:18120718-18122851:- | -1 | -4.28 | 4.46E-5 | Thiopurine S-methyltransferase activity |
| THYM | cis | rs11723261 | 1 | rs7665727 | chr4:277057 | ZNF718 | chr4:53272-156488:+ | 0.65 | 7.31 | 8.46E-11 | Immune response to smallpox vaccine (IL-6) |
| THYM | cis | rs11723261 | 1 | rs7669892 | chr4:309253 | ZNF718 | chr4:53272-156488:+ | -0.34 | -4.27 | 4.55E-5 | Immune response to smallpox vaccine (IL-6) |
| THYM | cis | rs11723261 | 1 | rs7674560 | chr4:263319 | ZNF718 | chr4:53272-156488:+ | 0.52 | 5.98 | 3.82E-8 | Immune response to smallpox vaccine (IL-6) |
| THYM | cis | rs11723261 | 1 | rs7686546 | chr4:240614 | ZNF718 | chr4:53272-156488:+ | 0.68 | 7.3 | 8.88E-11 | Immune response to smallpox vaccine (IL-6) |
| THYM | cis | rs73726531 | 1 | rs76969503 | chr6:18143512 | NHLRC1 | chr6:18120718-18122851:- | -1.05 | -4.61 | 1.24E-5 | Thiopurine S-methyltransferase activity |
| THYM | cis | rs73726531 | 1 | rs77032929 | chr6:18152293 | NHLRC1 | chr6:18120718-18122851:- | -1.01 | -4.34 | 3.6E-5 | Thiopurine S-methyltransferase activity |
| THYM | cis | rs7705093 | 1 | rs7705093 | chr5:96290647 | ERAP2 | chr5:96211644-96255398:+ | 1 | 17.34 | 3.46E-31 | Birdshot chorioretinopathy |
| THYM | cis | rs11723261 | 1 | rs77078697 | chr4:252048 | ZNF718 | chr4:53272-156488:+ | 0.53 | 5.92 | 5.01E-8 | Immune response to smallpox vaccine (IL-6) |
| THYM | cis | rs73726531 | 1 | rs77134359 | chr6:18135341 | NHLRC1 | chr6:18120718-18122851:- | -1.1 | -4.37 | 3.12E-5 | Thiopurine S-methyltransferase activity |
| THYM | cis | rs8050907 | 1 | rs77214986 | chr16:4603722 | NMRAL1 | chr16:4511696-4526307:- | -0.43 | -5.14 | 1.5E-6 | Obesity-related traits |
| THYM | cis | rs11723261 | 1 | rs77234191 | chr4:258294 | ZNF718 | chr4:53272-156488:+ | 0.68 | 7.3 | 8.88E-11 | Immune response to smallpox vaccine (IL-6) |
| THYM | cis | rs73726531 | 1 | rs77339739 | chr6:18135520 | NHLRC1 | chr6:18120718-18122851:- | -1.1 | -4.37 | 3.12E-5 | Thiopurine S-methyltransferase activity |
| THYM | cis | rs6911965 | 1 | rs77374467 | chr6:24475278 | GPLD1 | chr6:24428405-24489850:- | 0.57 | 5.22 | 1.07E-6 | Hematological and biochemical traits |